Major: Toxic liver damage, supportive treatment in chronic inflammatory liver disease, hepatic cirrhosis.
Minor: Dyspeptic complaints.
Actions: Hepatoprotective, antihepatotoxic, antioxidant.
Silymarin acts as an antagonist in many experimental liver-damage models: phalloidin and amanitin (Amanita phalloids, death-cap mushroom toxins), lanthanides, carbon tetracgloride, galactosamine, thioacetamide, and the hepatotoxic virus FV3 of cold-blooded vertebrates.
Alters the structure of the outer cell membrane of the hepatocytes in such a way as to prevent penetration of the liver poison into the interior of the cell.
Stimulates the action of nucleolar polymerase A, resulting in an increase in ribosomal protein synthesis, thus stimulating the regenerative ability of the liver and the formation of new hepatocytes.