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Cascara Sagrada BarkRhamnus purshiana |
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Can cause cramp-like discomfort of the gastrointestinal tract. (Patients should reduce dosage to ease side effect.)
Emodin can cause dermatitis.
During pregnancy and lactation.
Patients with intestinal obstructions.
Patients with acute intestinal inflammation (e.g. Crohn's disease, colitis ulcerosa, appendicitis, or abdominal pain of unknown origin).
Children under 12 years of age.
Excessive use may potentiate the action of cardiac glycosides due to excessive potassium loss.
Anthraquinones cause discoloration of the urine, which may interfere with diagnostic tests.
With chronic use/abuse potassium loss may cause an increase in effectiveness of cardiac glycosides.
Patients taking: antiarrhythmics, thiazide diuretics, corticoadrenal steroids, or licorice root.
Disturbances of electrolyte balance, especially potassium deficiency, albuminuria, and hematuria.
Pigment implantation into the intestinal mucosa (pseudomelanosis coli), which is harmless and usually reverses when drug is discontinued.
Potassium deficiency can lead to disorders of heart function and muscular weakness, especially with concurrent use of heart glycosides, diuretics, or corticoadrenal steriods.
Overdose can cause electrolyte and fluid imbalance.
Diarrhea with excessive loss of potassium.
Patients may develop atonic non-functioning colons.